Research Programs

New technologies are accelerating breakthroughs in the basic biomedical sciences, advancing new and more precise therapeutic interventions, and leading to unprecedented gains in human health and well-being. Nowhere is this more critical than in precision medicine, which integrates the fundamental complexity of biological systems (e.g., genomics, proteomics, metabolomics, and systems analysis), data science and analytics, and engineering science and technologies to provide more accurate and precise treatment modalities to patients. The more complex the disease, the more distinct are the number of disease variations even to the level of the individual patient. This increasing complexity, together with the need for a high degree of accuracy, precision, and computation, requires skills that lie at the heart of engineering and engineering science.

The Center for Engineering and Precision Medicine (CEPM) sits at the interface of biological and engineering sciences with clinical translation (Figure 1). The center builds on a wealth of enabling and multiscale technologies pioneered by researchers at Mount Sinai and Rensselaer at the nexus of medicine, engineering, and data analytics/artificial intelligence. This confluence of scientific and technological expertise is being targeted toward specific translational applications, including minimally invasive control and regulation of neural circuity, engineering the immune system to treat cancer and infectious disease, and on-demand personalized tissue repair and regeneration. This research requires a co-location of engineering with biomedical science and an undergirding clinical enterprise, leading to both basic understanding of disease mechanisms and opportunities for therapeutic interventions and improvement in clinical care.

Diagram showing: From fundamental research at Rensselaer and Mount Sinai to translational medicine.

Figure 1. From fundamental research at Rensselaer and Mount Sinai to translational medicine.

CEPM focuses on three core research directions: neuroengineering, immunoengineering, and reparative and regenerative medicine. This research comprises two-thirds of the $42 billion National Institutes of Health external research budget. The translation from basic and applied research into patient care is a key outcome of CEPM, as represented in Figure 2. Core research in biosciences and biomedicine, bioimaging, artificial intelligence, and machine learning, modeling and simulations of complex systems, and new materials development provide a fundamental undergirding that enables a host of biosystems and processes that advance clinical translation in areas of immediate relevance in today’s medicine.



Minimally invasive control and regulation of neural circuitry

Key CEPM Expertise

Circadian disruption (CD), magnetogenetics, drug delivery systems

Neuroimaging, deep brain stimulation, non-invasive neuro-modulation, brain network analyses, neurosurgical guidance, optogenetics

Future Areas Of Growth

Neuroscience, Nanorobotics, neuroimaging



Engineer immune system to treat cancer and infectious diseases

Key CEPM Expertise

Bioprocessing, Structural biology, AI/Bioinformatics, Nanomedicine

UVC for COVID-19 decontamination, imaging of COVID-19, nanomedicine, trained immunity, artificial intelligence for imaging, informatics

Future Areas Of Growth

Micro-physiological Systems, Biocomplexity, Immunogenomics

Reparative and Regenerative Medicine


On demand personalized tissue repair and regeneration

Key CEPM Expertise

Biomanufacturing, Cell-ECM/ Matr. Interaction, Robotics

Genomics and stem cells, tissue characterization, image-guided treatment of diseases, neuro re-habilitation, thin film electronics, portable low-cost diagnostic devices

Future Areas Of Growth

Cellular Engineering, Epigenetics/genomics

Figure 2. Core research foci of the Center for Engineering and Precision Medicine (CEPM).

Support CEPM

Coming together to advance a new
kind of medical research